Direktlänk till inlägg 7 februari 2011

Medel mot influensa på väg

Av William Karlsson - 7 februari 2011 16:47

Forskare i Storbritannien har framgångsrikt prövat ett vaccin som kan fungera mot all känd influensa.

– Har de lyckats är det fantastiskt, säger professor Björn Olsen som dock poängterar att det behövs större studier.

Vaccinet skiljer sig från de traditionella genom att rikta in sig på proteiner inne i influensaviruset i stället för på proteiner på virusets skal. De två proteinerna inne i viruset liknar varandra i olika stammar och är mindre benägna att mutera.

Det innebär att det nya vaccinet inte skulle behöva utvecklas för varje ny influensatyp som dyker upp.

– Har de lyckats är det fantastiskt. Det vore ett stort genombrott. Men det här är ett notoriskt svårt område och antalet försökspersoner är väldigt litet. Det krävs en mycket större studie innan man kan lita på resultaten, säger Björn Olsen, virolog och professor i infektionssjukdomar vid Uppsala universitet.

Han är också lite skeptisk till att forskarna gått ut med nyheten till en vanlig dagstidning innan de publicerat sig i en vetenskapliga tidskrift.

– När forskare går ut så här brukar det vara ett tecken på att de vill ha mer pengar, säger han.

Han påpekar att svårigheterna är många. Det gäller att få tillräckligt många minnesceller att komma ihåg vad de ska attackera.

– Om inte det främmande ämnet upplevs som särskilt främmande blir det ingen stark reaktion. Dessutom får man hoppas att det inte blir några svåra biverkningar.

Traditionella vaccin stimulerar kroppen att producera antikroppar för att bekämpa influensan, medan det nya ökar produktionen av T-celler som letar upp och dödar infekterade celler.

– Färre av de vaccinerade än de ovaccinerade fick influensa, sade Sarah Gilbert som lett forskningslaget.

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